Is chronic cerebral ischemia serious?

summary

Chronic cerebral ischemia refers to the long-term cerebral hypoperfusion caused by various reasons. It plays an important role in the occurrence and development of vascular dementia (VD), Binswanger disease, Alzheimer's disease (AD) and other nervous system diseases. The mechanism of pathological injury and neuroprotection after chronic cerebral ischemia is complex, and it is in the research stage at present. This article mainly reviews the research progress of pathological damage mechanism of chronic cerebral ischemia. Let's share my experience with you.

Is chronic cerebral ischemia serious?

In clinic, the condition of patients is generally very complex, most patients often show chronic cerebral ischemia combined with other chronic diseases, such as hypertension, diabetes, hyperlipidemia and other chronic diseases. Therefore, many researchers based on the 2VO chronic cerebral ischemia model, combined with other chronic disease models for joint research.

Chronic cerebral ischemia 2VO model was first established by de la Torre et al. This model used permanent ligation of bilateral common carotid arteries in rats to create a chronic forebrain hypoperfusion state, so as to prepare an animal model of chronic cerebral ischemia. The 2VO model has become the most commonly used model in the study of chronic cerebral ischemia. It plays an important role in the study of white matter damage, hippocampal neuronal degeneration, learning and memory dysfunction, and neural signal transmission dysfunction after chronic cerebral ischemia. At the same time, the model can also be used in the study of aging and Alzheimer's disease.

The end-to-end and end-to-side anastomotic models were established respectively according to the different anastomotic methods of the cervical artery and vein. However, the end-to-end anastomotic model was quickly replaced by the end-to-side anastomotic model because of the intracranial venous sinus hypertension caused by the end-to-end anastomotic model. Hai j et al. Used the end to side anastomosis model to study the expression of VEGF and angiogenesis after chronic cerebral ischemia, but the operation process of this model is complex, and its practical application value needs further study.

matters needing attention

In daily life, eat more fruits and vegetables, keep optimistic mood, pay attention not to fatigue, pay attention to the recovery of the body, in addition, if there are any symptoms should go to the hospital for examination, and corresponding treatment, these are to actively do.