Symptoms of thrombocytopenia in pregnant women?

summary

Pregnancy with less platelet cases is still very common, many reasons, here to summarize the common causes, for reference diagnosis and treatment. Platelets are produced by megakaryocytes in bone marrow hematopoietic tissue. The newly generated platelets first pass through the spleen, and about 1 / 3 of them are stored here. The stored platelets can be exchanged freely with the platelets entering the circulating blood to maintain the normal amount in the blood. It is generally believed that platelet production is regulated by thrombopoietin in blood, but its detailed process and mechanism are still unclear. The life span of platelets is about 7-14 days, about 1 / 10 of the total number of platelets renewed every day. Symptoms of thrombocytopenia in pregnant women? Let's talk about it.

Symptoms of thrombocytopenia in pregnant women?

The degree of thrombocytopenia was mild, and the platelet count was more than 75 × No symptoms and signs were found during routine prenatal examination. There was no history of thrombocytopenia or bleeding, no risk of bleeding, and no thrombocytopenia or bleeding in fetus or newborn. There is no need for additional examination and special treatment for thrombocytopenia gravidarum.

Autoimmune disease characterized by skin and mucous membrane hemorrhage and anemia, acute type is more common in children, chronic type is more common in adult women, accounting for about 5% of thrombocytopenia during pregnancy. 85% of patients have IgG antibody on the surface of platelets, PLT < 100 * 109 / L, generally < 50 * 109 / L before they have symptoms, bone marrow megakaryocytes are normal or increased, at least not reduced, Most of the platelet antibodies were positive, hormone therapy was effective, splenectomy was effective.

It is worth noting that IgG antibody can enter the umbilical cord blood, so it can cause some neonatal diseases (mostly transient and self limiting, with good prognosis). At the same time, about 25% of ITP patients have thyroid dysfunction at the same time. Pay attention to the routine screening of patients with platelet abnormalities, and other tests include biochemical, urine routine, HIV, and antinuclear antibody (SLE).

matters needing attention

Postpartum: the use of corticosteroids during pregnancy, postpartum continue to use, dynamic detection of neonatal platelets, milk can have platelet antibodies, depending on the severity of the disease decide whether breast-feeding. Newborn: if PLT < 50 * 109 / L, color Doppler ultrasound or CT should be done. If PLT < 20 * 109 / L or bleeding tendency, IVIG (1 g / kg) should be used to recover well.