Symptoms of gastrinoma

summary

Gastrinoma, as we call it, is a kind of tumor with the function of secreting gastrin. It is mainly characterized by excessive secretion of gastric juice and acid, hypergastrinemia, multiple and atypical sites, refractory peptic ulcer or diarrhea and other syndromes. What are the symptoms of our gastrinoma? I'll share what I know with you.

Symptoms of gastrinoma

The most common clinical manifestation of gastrinoma patients is peptic ulcer. Its symptoms are often similar to those of common peptic ulcer patients, but the symptoms are persistent and progressive, and the response to treatment is poor.

The distribution of upper gastrointestinal ulcer in gastrinoma patients is similar to that of common peptic ulcer. About 75% of gastrinoma patients' ulcer is located in the first segment of duodenum, and gastric ulcer is rare.

Prospective studies have shown that the clinical course of gastrinoma patients with lymph node metastasis is different from that of patients with liver metastasis. Patients with only local lymph node metastasis but no liver metastasis were rarely died due to tumor invasion.

matters needing attention

A small number of patients with gastrinoma have fatty diarrhea, which can precede peptic ulcer symptoms for 8 years. About 7% of patients with gastrinoma develop diarrhea without ulceration. Diarrhea is mainly caused by a large amount of hydrochloric acid in the upper digestive tract.