Symptoms of immunodeficiency

summary

Secondary immunity is more common than primary immunity in immunodeficiency diseases, mostly because of infection or malignant tumor, as well as autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and immunosuppressive therapy. It can be temporary, as long as the primary disease treatment, secondary immune disease can not relapse. It is often manifested in the symptoms of systemic infection, the occurrence of malignant tumor, acute anemia and other clinical symptoms.

Symptoms of immunodeficiency

In the early or acute stage, some nonspecific manifestations such as sore throat, fever and muscle soreness may appear 3-6 weeks after virus infection. The virus replicated in vivo, but the patient still had a good immune response, and the symptoms of acute infection could be relieved by himself after 2-3 weeks;

In the middle stage or chronic stage, the immune function of the body and the virus are in a stage of mutual confrontation. In some cases, this stage can last for several years or no longer enter the terminal stage. At this stage, the virus replication continued at a low level, with no obvious clinical symptoms or obvious systemic lymphadenopathy, often accompanied by fever, fatigue, rash, etc;

At the later stage, or at risk stage, the body's immune function completely collapsed, the patient continued to have fever, fatigue, emaciation, diarrhea, and nervous system symptoms, obvious opportunistic infection and malignant tumor. Blood tests showed that the number of lymphocytes decreased significantly (< 30%), especially the number of CD4 + cells. The ratio of CD4 + cells to CD8 + cells decreased from 2 to less than 0.5, The cellular immune response was lost.

matters needing attention

The genetic factors of immune deficiency account for a large proportion, especially in severe cases. Therefore, for those who tend to be immunodeficient, such as those who repeatedly suffer from multiple suppurations, those who have diarrhea without obvious infectious factors, and those who often use antibiotics to resist infection, immunological examination should be conducted before marriage. The immune laboratory should be requested to detect the immune cells, serum immune factors and related cytokines, as well as the immune function in vitro and in vivo. At the same time, we need to make genetic inquiries, including both men and women's personal history, family history, deformity and so on. For those with cleft palate and cleft lip, thymus and thymus function can be further examined.