Why is nephrotic syndrome edematous?

summary

All kinds of pathological damage lead to the local microcirculation disorder of damaged kidney, we need to seize the time for treatment. Ischemia and hypoxia damage the renal vascular endothelial cells, trigger inflammatory reaction, and lead to the damage of renal intrinsic cells, such as mesangial cell proliferation, mesangial matrix increase, basement membrane filtration pore size increase or occlusion, or basement membrane rupture, charge barrier damage When the permeability increases, a large amount of plasma protein will leak out. The leakage of plasma albumin is much more than the reabsorption of renal tubules, resulting in a large amount of proteinuria. Why is nephrotic syndrome edematous?, Now let's take a concrete look.

Why is nephrotic syndrome edematous?

First: when a large amount of proteinuria is produced, the protein concentration in human blood will be reduced, which will lead to human hypoproteinemia. When the concentration of protein in blood decreases, the osmotic pressure of plasma colloid in blood vessel will decrease.

Second: the decrease of plasma colloid osmotic pressure indicates that the proportion of water in blood is larger than that in tissue, so the water in blood will penetrate into the interstitial space of tissue, and the more the water in tissue seeps, the more it accumulates, which will eventually lead to human edema.

Third: if the process of renal disease is not controlled, the renal intrinsic cells will undergo phenotypic transformation under the action of some nephrotoxic factors and growth factors, especially the fibroblasts in the renal interstitium will secrete and synthesize a large amount of extracellular matrix, which eventually leads to the deposition and accumulation of a large amount of extracellular matrix in the kidney.

matters needing attention

The accumulation of extracellular matrix replaces the healthy nephron, leading to glomerulosclerosis and tubulopathy. Loss of renal filtration function, a large reduction in micturition or unable to urinate, so that the water in the tissue should not be discharged, leading to tissue edema.