Overview of pregnancy with hypercortisolism?

summary

Hypercortisolism, also known as Cushing's syndrome, is the most common form of adrenocortical hyperfunction. This is because the adrenal cortex secretes too much cortisol, but it often secretes other corticosteroids at the same time. Pregnancy complicated with hypercortisolism is very rare. Most of the pregnancies end in abortion, premature delivery or stillbirth. Overview of pregnancy with hypercortisolism? Let's talk about it

Overview of pregnancy with hypercortisolism?

The clinical manifestation of hypercortisolism is due to excessive cortisol in the body, resulting in metabolic disorders of sugar, protein, fat and electrolyte, and dysfunction of various organs. The main clinical manifestations were full moon face, centripetal obesity, purple lines, acne, diabetes tendency, hypertension, osteoporosis, amenorrhea, fatigue and so on.

Due to the metabolic changes of glucocorticoid and salt corticoid during pregnancy, the production of cortisol and aldosterone increases with the growth of pregnancy, so the diagnosis of cortisol in pregnancy is difficult.

The typical cases of pregnant women with hypercortisolism were full moon face, abdominal and inner side of limbs purple lines, acne, weight gain and elevated blood glucose; The levels of 17 hydroxycorticosteroids (17-OHCS) and free cortisol in 24 hours urine were significantly increased; B-mode ultrasonography of adrenal gland and perirenal aerography are helpful for the diagnosis.

matters needing attention

Once pregnancy complicated with cortisol syndrome appears in pregnancy, it is easy to cause abortion, stillbirth and other adverse consequences. Therefore, in daily life must be prevented, pregnant women do not take drugs, pay attention to balanced diet nutrition, especially after entering the second trimester of pregnancy, must be on time for pregnancy examination, in order to avoid pregnancy induced hypertension.