How is infantile acute myeloid leukaemia caused?
summary
Acute myeloid leukemia (AML) is similar to adults (< 50 years old) in molecular biological changes and chemotherapy response. Infants with AML are more likely to develop extramedullary leukemia than adults. Let's share my experience with you.
How is infantile acute myeloid leukaemia caused?
No high incidence of tumor was found in siblings, parents and offspring of all types of leukemia patients. Although leukemia has been reported in siblings, the incidence is very low. The probability of leukemia in identical twins is higher than that in fraternal twins. Genetic defects in grandparents, parents and siblings are associated with various types of all, including musculoskeletal diseases, gastrointestinal diseases, allergic diseases, hereditary heart diseases and lung diseases.
Acute leukemia is not a hereditary disease. However, it has been proved that some hereditary syndromes, such as Down syndrome and Fanconi anemia, are closely related to the susceptibility of leukemia. Studies in the United Kingdom and the United States show that 2.3% - 2.6% of childhood acute leukemia is related to genetic factors. Down syndrome, congenital heart disease and gastrointestinal malformation were found in 2 117 cases of all and 650 cases of AML; Down syndrome, mental retardation and congenital heart disease are common in AML.
In recent years, there have been enough cases of long-term survival. Some scholars have investigated the risk of leukemia in the offspring of long-term survival patients. The results show that the risk of leukemia in this population has not increased. At the same time, the chromosomal stability of healthy children with leukemia was examined. No increase of chromosomal instability was found in the control group or bleomycin induced aberration group. Compared with the healthy population, there was no increase in congenital malformations in the offspring of long-lived all children.
matters needing attention
Avoid contact with harmful factors, avoid contact with harmful chemicals, ionizing radiation and other factors causing leukemia, and strengthen various protective measures when contacting poisons or radioactive substances; Avoid environmental pollution, especially indoor environmental pollution; Attention should be paid to rational use of drugs and cytotoxic drugs.
