What are the causes of barium chloride induced arrhythmia
summary
My father-in-law has always been in poor health. He often says that he is not comfortable. These days, he says that his chest is stuffy. Sometimes he feels out of breath. He goes to the hospital for examination. The doctor says that he has arrhythmia and he is hospitalized. Today, let me learn the causes of barium chloride induced arrhythmia.
What are the causes of barium chloride induced arrhythmia
The first reason is: oral barium chloride 0. 2~0。 The lethal dose is about 0. After 8 g barium ion enters the body, it will produce excessive stimulation and excitatory effect on skeletal muscle, smooth muscle, myocardium and other muscle tissues. Excitation of the myocardium can enhance the stress and conduction of the myocardium, and accelerate the heart rate. In severe cases, it can turn to inhibition, resulting in conduction block, severe ectopic heart rate and ventricular fibrillation, and even ventricular arrest.
The second reason is: the arrhythmia caused by barium chloride is that on the one hand, Ba2 + has a similar effect to Ca2 +, and has digitalis effect on the heart, which can inhibit Na + - K + - ATPase on myocardial cell membrane, reduce intracellular K +, lead to decrease of maximum diastolic potential, increase of intracellular Na +, increase intracellular Ca2 + through Na + - Ca2 + exchange, and lead to increase of oscillatory afterpotential and trigger activity Self discipline increased.
The third reason is that both of them can enter cardiomyocytes through slow channels, which increases the excitability of cardiac sympathetic nerve and leads to ectopic rhythm and arrhythmia. On the other hand, barium chloride can promote Na + influx in Purkinje fibers and increase the depolarization rate in diastole. It can inhibit K + efflux, increase 4-phase gradient, and improve the automaticity of atrial conduction tissue and atrioventricular bundle Purkinje fiber system.
matters needing attention
In addition to the basic treatment of arrhythmia in daily life, we should pay more attention to the underlying causes of arrhythmia.
