What are the causes of psoriasis

summary

Not long ago, I had some white dots on my arm. At first, I didn't pay attention to them. The longer they were, the more they were. I went to the hospital for an examination. The doctor told me that psoriasis was not good at this time, because I didn't think I would suffer from this kind of psoriasis. After taking medicine for a period of time, fortunately, it didn't continue to spread, and there were some problems It's going down. Let me share the causes of psoriasis.

What are the causes of psoriasis

Factor 1: 1. Genetic factor is a polygenic genetic disease in which genetic factors interact with environmental factors. 2. Immune factors in recent years, psoriasis has been considered as an immune or inflammation mediated disease. 3. The study of infection factors confirmed that Streptococcus infection, Staphylococcus aureus infection and fungal infection are related to the pathogenesis of psoriasis, and whether virus infection is related to the pathogenesis of psoriasis is not clear. Especially bacterial infection can induce or aggravate psoriasis. Infection can be found in 45% of psoriasis patients. Streptococcal infection, especially pharyngitis, is the most common cause. Streptococcus can be isolated from periodontal abscess, perianal cellulitis and pustules. Streptococcal infection can cause drop like psoriasis, especially in children and adolescents. It can also cause pustular psoriasis or aggravate plaque psoriasis. Sometimes, infection of nasal sinus, respiratory tract, gastrointestinal tract and genitourinary system can also aggravate psoriasis. HIV infection can also aggravate psoriasis.

Factors 2: 1. Endocrine factors pregnancy can make skin lesions disappear or reduce, but also make skin lesions worse. Thyroid disease, diabetes and other endocrine diseases have no obvious effect on the disease. Hypocalcemia is a predisposing factor for generalized pustular psoriasis. Although vitamin D3 derivatives can improve psoriasis, vitamin D3 deficiency does not cause psoriasis. Psoriasis improves in 50% of pregnant women. But some pregnant patients will have eruptive pustulosis (some think it is also a kind of pustular psoriasis). 2. Patients with mental factors can have neuropsychiatric changes, and these changes can aggravate the existing skin lesions. 3. The study of living habits, drug factors and environmental factors found that damp, infection, drinking, taking medicine and mental stress were the main risk factors of psoriasis. The drugs that may induce or aggravate psoriasis include β 1 receptor blockers, non steroidal anti-inflammatory drugs, lithium salts, antimalarial drugs, tetracycline, calcium channel blockers, metformin, interferon α, etc. Environmental factors are related to the age of onset, and season and climate have influence on the incidence and recurrence of psoriasis.

Factor 3: psoriasis was initially considered to be an epidermal disease caused by biochemical or cellular defects of keratinocytes. In the early 1980s, some biochemical mediators, enzymes and pathways were found to be abnormal in psoriasis, including camp, arachidonic acid like substances, protein kinase C, phospholipase C, polyamine and transforming growth factor α. Some scholars have found that damp is also one of the pathogenic factors of psoriasis, and whether eating fish and shrimp is the inducing factor of psoriasis needs further study. When it was found that cyclosporine and other drugs that have been used to treat T cells can improve psoriasis, people began to turn their attention to T cells. For the past 20 years, psoriasis has been considered to be a T cell driven disease. Lymphocyte subsets and cytokines involved in chemotaxis, homing and activation of inflammatory cells have been deeply studied, and new therapeutic methods have been developed. Some reports even think that psoriasis is an autoimmune disease, but no real autoantibodies have been found in patients with psoriasis. However, recent findings show that psoriasis, as a polygenic disease (see Table 1), involves some gene polymorphisms of immune system and keratinocyte abnormalities, which can be the cause of psoriasis. It is now considered that the epidermis is also an important part of the innate immune response, which can affect the activation of the adaptive immune system. Therefore, psoriasis can be caused not only by the abnormal adaptive immune system, but also by the abnormal innate immune function of epidermal cells.

matters needing attention

1. Avoid fish, shrimp, strong tea, coffee, wine, spicy food, etc. 2. Do not wash with hot water or soap. Topical application of neurodermatitis lotion, or ointment containing corticosteroids, and application of fujiling or temeifu film are effective. It can be applied to patients with severe X-ray or local application depth of 90. If there is local redness and swelling, antibiotics should be used. 4. Try to avoid scratching the affected area. Truthfully, when the itching is intolerable, it can be applied with a cold towel, or immediately wipe medicine, instead of hot water to stop itching. 5. Avoid drinking, drinking strong tea and eating spicy food. Gastrointestinal dysfunction should be corrected. 6. We must insist on the use of drugs. We can't stop the use of drugs on our own because it doesn't itch. 7. Trim nails regularly. Psoriasis patients to often trim nails, infants can wear gloves to prevent scratching. Because there are a lot of bacteria in the nail, once scratch the affected area will make the skin worse because of infection. 8. Regular skin care. The skin of psoriasis patients is generally dry. Often apply moisturizing cream or ointment. It is best to choose oily or dry skin cream to lock the moisture of the skin, which helps to remove scales. Especially in the dry and cold season, psoriasis patients had better put an air humidifier in the room to improve the humidity of the indoor environment, so as to better play a nursing role on the affected skin. 9. Pay attention to avoid injury. Psoriasis patients in the process of exercise must pay attention not to be injured, such as once the skin damage, may make the disease worse. 10. Clothes, especially underwear, should be loose. Do not wear silk, wool or chemical fiber underwear.