Is septicemia serious

summary

A friend got the disease of septicemia not long ago, fever is particularly severe, so, is septicemia serious? Let's talk about it.

Is septicemia serious

First of all, septicemia often causes circulatory and respiratory failure, and the reactivity of vasoconstrictors (such as some cytokines, platelet activating factor, endothelin, adenosine, etc.) increases, resulting in hemodynamic changes and decreased renal blood flow, which is one of the causes of septicemia complicated with renal failure. In addition, there are also non hemodynamic factors, such as renal infection caused by bacteria migrating to the kidney with blood. In patients with septic renal failure, renal biopsy found that there were micro abscesses in the renal interstitium and renal tubules.

Secondly, sepsis complicated with renal failure has obvious activation of neutrophils. The role of neutrophils in acute renal failure is still controversial. Recently, it has been found that the increase of neutrophils in septicemia can aggravate renal ischemia and renal insufficiency. The mechanism is that the interaction between integrin and ICAM-1 weakens the protection of renal vessels. In addition, neutrophils can destroy the endothelium and reduce the synthesis of no, promote the generation of free radicals, and aggravate ischemic acute renal failure.

Finally, septicemia can cause rhabdomyolysis syndrome, of which 69% are caused by Gram-positive bacteria, and most of them have acute renal failure (68.5%). Sepsis caused by Gram negative bacteria did not occur in most cases, but the proportion of multiple organ failure (40%) was similar to that caused by Gram positive bacteria (45.7%), which indicated that the syndrome was only one of the factors leading to renal failure. So septicemia is a serious disease, in the emergence of abnormal physical conditions, we should pay attention to, especially to the timely inspection and treatment to the hospital.

matters needing attention

The most important thing for patients after getting sick is to pay attention to it and treat it in time. They should eat more high protein and iron foods in their daily diet, pay attention to the regularity of life, and have a good mood.