Why is serum IgE high in children urticaria?

summary

Urticaria is not only a common disease in adults, but also a common disease in children. It can be seen from newborn infants to children over 10 years old. The characteristics of urticaria in children are: allergic reaction caused by skin pathological reactive skin disease, with wheal, erythema more common. Why is serum IgE high in children urticaria? Next, I'd like to share my views with you.

Why is serum IgE high in children urticaria?

Urticaria is easy to diagnose, but it is difficult to determine the cause. General often do check: ask medical history, detection of antinuclear antibody and IgE antibody, IgE antibody is very helpful for the diagnosis of urticaria.

Urticaria in children is caused by mast cell degranulation releasing histamine and other inflammatory mediators. The increase of capillary permeability produces the air mass. Vasodilation causes erythema, and inflammatory mediators stimulate receptors to cause pruritus. The classical theory is that the antigen binds to the specific antibody IgE on the surface of skin mast cells to stimulate mast cells to release histamine and other inflammatory mediators,

The pathogenesis of chronic urticaria is mostly studied by the theory of IgE mediated autoimmunity, which has sufficient evidence to prove that most of the patients with urticaria in children have functional anti IgE receptor antibodies and (or) anti IgE antibodies that can degranulate mast cells or basophils in the skin, and the total IgE of serum immunological examination is higher than normal;

matters needing attention

It is very important to prevent mites in family; We should keep fewer cats, dogs and other pets at home. Avoid children's contact with pollen materials, and avoid activities at the bottom of trees and grass. Keep warm to avoid cold urticaria; Children with urticaria should wear loose and breathable clothing to avoid irritation to the affected area.