Symptoms of sex chromosome abnormalities

summary

Sex chromosomes, as the name suggests, are sex related chromosomes, which can determine the sex differentiation of human body. Sex chromosomes are not only related to gender and fertility, but also determine a person's intellectual development, physical development and personality characteristics. If there is a problem with the sex chromosome, some women may be more man than man, while some men may be more woman than woman. Symptoms of sex chromosome abnormalities? Let's talk about it

Symptoms of sex chromosome abnormalities

It is characterized by high stature, small testis, secondary sexual dysplasia and infertility. The patient has long limbs, high stature, sparse beard and pubic hair, and fat accumulation on the body surface after adulthood; The pitch is higher and the laryngeal segment is not obvious; About 25% of the cases had breast development and delicate skin; Most of the vulva were normal without deformity,

The size of testis is normal in newborn, but it is small and hard in puberty, and its volume is 1 / 3 of that of normal people; The basement membrane of seminiferous tubule of testis was thickened, hyaline degeneration and azoospermia. The plasma testosterone of typical cases is only half of that of normal people; In some patients, testosterone was normal and estrogen increased.

A few patients may have bone marrow abnormality, congenital heart disease, normal intelligence or mild hypofunction. Some patients have mental disorders or schizophrenia tendency. According to the analysis of clinical manifestations of patients with different karyotypes, individual chimeric patients may have fertility; The more the number of X chromosome is, the more serious the disorder of sexual and intellectual development is, and the more physical abnormality is. In addition, patients are prone to diabetes, thyroid disease, asthma and breast cancer.

matters needing attention

In order to avoid the harm of chromosome, we should check the body regularly at ordinary times, and know the situation of the body at any time, because chromosome abnormality is easy to lead to spontaneous abortion or fetal arrest in the process of pregnancy.