What are NSAIDs?

summary

The research of NSAIDs began with the use of sodium salicylate at the end of the 19th century. In fact, we usually use aspirin. At present, there are two kinds of NSAIDs. Clinically, NSAIDs are mainly used to treat connective tissue diseases, such as rheumatoid arthritis, rheumatic fever, osteoarthritis, lupus erythematosus and ankylosing spondylitis, Our most common NSAIDs are also known as antipyretic analgesics. For example, aspirin has not only analgesic and anti-inflammatory effects, but also anti rheumatic effects. Now let's take a look at other categories of NSAIDs.

What are NSAIDs?

First: the first class of non steroidal anti-inflammatory drugs is pyrazolone, which is a drug with antipyretic and analgesic effect accidentally discovered by scientists in the process of studying quinine analogues. Inspired by the methylamino group in the structure, aminopyrine was synthesized by introducing dimethylamino into antipyrine. Its Antipyretic and analgesic effect is better than antipyrine, but its effect is slightly slower.

Second: the second kind of non steroidal anti-inflammatory drugs are drugs, o-aminobenzoic acid derivatives have strong anti-inflammatory and analgesic effects, which are used in the treatment of rheumatoid arthritis and rheumatoid arthritis clinically. The side effects of this kind of drugs are more, mainly gastrointestinal disorders, such as nausea, vomiting, diarrhea, lack of appetite and so on.

Third: the third class of NSAIDs is arylalkanoic acid, which is a large class of drugs. There are dozens of them on the market. According to the structural characteristics, they are usually divided into ARYLACETIC acid and arylpropionic acid. Indoleacetic acid is the representative of ARYLACETIC acid, and ibuprofen is the representative of arylpropionic acid. matters needing attention:

matters needing attention

Inflammation is a kind of defense mechanism of the body against infection, mainly manifested as redness, swelling, pain and so on. There are two kinds of drugs for the treatment of inflammation in clinic, one is steroidal glucocorticoid anti-inflammatory drugs, the other is non steroidal anti-inflammatory drugs.