Why no one studies scleroderma?

summary

Scleroderma / systemic sclerosis (SSC) pathogenesis is complex, early treatment, let your body recover as soon as possible, normal life. The clinical manifestations are changeable, and it is not a disease suitable for popular science. Therefore, doctor Yu has always avoided this topic. Now let's talk about why no one studies scleroderma?.

Why no one studies scleroderma?

First, scleroderma is derived from the Greek word "scleros" and is used to describe thickened and hardened skin. Scleroderma is composed of a group of heterogeneous diseases with common manifestations of thickening and sclerosing skin lesions. In addition to "scleroderma", other clinical manifestations are very different, and the etiology is unknown and the pathogenesis is very complex.

Second, in terms of pathogenesis, it is clear that inflammation and vascular injury are the main manifestations in the early stage of the disease, while fibrosis and insufficient blood supply are the prominent manifestations in the late stage.

Third, with the rapid development of cell and molecular biology, genetics and immunology, the pathogenesis of the disease has become more and more clear. It is the early vascular injury, immune cell activation, immune cell apoptosis, immune cell apoptosis induced by genetic susceptible individuals triggered by environmental factors A cascade of chronic and progressive tissue damage resulting from autoimmune response and subsequent fibroblast activation and matrix accumulation. Over time, vascular dysfunction and fibrosis of important organs lead to morbidity and mortality.

matters needing attention

We do not over differentiate clinically, often referred to as systemic sclerosis, but also want to remind doctors and patients to remember that the disease can involve multiple system lesions, so we need to be vigilant at all times.