How to collect allogeneic bone marrow transplantation

summary

In order to successfully match bone marrow transplantation, it is necessary to remove bone marrow from other people's bodies. So what technology is used for bone marrow collection has become what many people want to know. With such advanced science and technology, let's talk about how to collect allogeneic bone marrow transplantation.

How to collect allogeneic bone marrow transplantation

First, stem cells can be collected from the donor's bone marrow or peripheral blood. Bone marrow is collected by bone marrow transplantation (BMT). Bone marrow is extracted from the donor's iliac bone with fine needles. These bone marrow rich in stem cells will be stored for transplantation. In the process of collection, the donor is under anesthesia and will not feel pain. At present, this method has been basically not used.

Second: blood cell separator, collecting peripheral blood stem cells, pretreating donors, using some cytokines such as granulocyte colony-stimulating factor (G-CSF) and other drugs to increase the number of stem cells in peripheral blood. When the number of stem cells is enough, they can be collected by blood cell separation, and the stem cells are isolated, while the rest of the blood is transfused back to the donor. The collected stem cells will also be stored at the time of transplantation. It takes 3-4 hours for one isolation. In order to collect enough stem cells, one to three isolation operations are usually required.

Third: the separation and collection of peripheral blood cells is quite safe, using a disposable totally closed tube, which will not cause any infection, and this method is suitable for younger donors or other people who can not withstand bone marrow collection. Allogeneic bone marrow transplantation (BMT) is a kind of treatment method, which is pretreated with high-dose chemoradiotherapy or other immunosuppressants to remove tumor cells and abnormal clonal cells in the recipient body, block the pathogenesis, and then transplant allogeneic hematopoietic stem cells to the recipient, so that the recipient can reconstruct normal hematopoietic immunity and achieve the purpose of treatment.

matters needing attention

Only the right bone marrow can be used for bone marrow transplantation, so that patients can be healthy. The above is all the process of taking bone marrow from allogeneic bone marrow. In general, the sample is taken first and then processed. If appropriate, the patient can be given bone marrow transplantation.