How is enteropathic acrodermatitis caused?

summary

Acrodermatitis enteropathica is a rare hereditary zinc deficiency. Its clinical manifestations are acrodermatitis, alopecia and diarrhea. The skin rash usually occurs around the cavity and at the end of the limbs. It is characterized by erythema, plaque, blister, erosion, scab, etc. How is enteropathic acrodermatitis caused? Next, I'd like to share my views with you.

How is enteropathic acrodermatitis caused?

It belongs to autosomal recessive inheritance. The mutation of slc39a4 gene, which encodes zinc transporter, leads to intestinal absorption dysfunction of zinc. Zinc is an essential trace element for human body, which plays an important role in maintaining immune function, antioxidation, regulating cell proliferation, differentiation, apoptosis and other physiological functions.

Some people think that there is a zinc ligand in human milk. Although the content of zinc in human milk is not high, it is easy to be absorbed by infants. In addition to human milk, there is a small peptide in other protein foods, including cow's milk. This small peptide can easily complex zinc in food to form a complex state of zinc which is not easy to be absorbed by human body. Usually, this small peptide is hydrolyzed by the short peptidase secreted by normal intestinal cells. However, patients often lack this short peptidase, so that the intake of zinc is complexed by small peptides, which affects the absorption of zinc, resulting in the lack of zinc.

Children with chronic zinc deficiency treated with parenteral nutrition therapy may develop rash and diarrhea similar to this disease. The symptoms disappear or alleviate after zinc treatment. After feeding zinc free food for several weeks, the skin squamous lesions and hair dryness and abscission can be seen, which is similar to the symptoms of this disease. After zinc treatment, it has a rapid effect.

matters needing attention

1. The zinc content of colostrum is 6-7 times of that of mature milk, so milk should be opened early. 2. We should prevent the bad habits of partial eating, picky eating and eating too many snacks. 3. Zinc is mainly found in animal food, but little in plant food and fruit. Such as lean meat, liver, fish, egg yolk, etc.