Causes of high blood uric acid

summary

High uric acid is a terrible disease, and the harm to patients is also relatively serious. My uncle suffered from high blood uric acid, which was discovered only when he went to the hospital for examination these days. No wonder in recent years, there has always been the phenomenon of blood urination. It turned out that this disease was the cause, and my uncle was given remission treatment by means of drugs. Now I'll talk about it Tell you about the reason of high blood uric acid.

Causes of high blood uric acid

In our daily life, we all want to understand some of the reasons for the disease of high blood uric acid. Excessive intake of purine: the high content of blood uric acid is directly proportional to the purine content in food. 50% of RNA and 25% of DNA in food should be excreted as uric acid in urine. Strict restriction of purine intake can reduce serum uric acid content to 60umol / L (1.0mg / dl) and urinary uric acid secretion to 1.2mmol/d (200mg / D).

Because the main use of purine is the composition of DNA and RNA. When the cellular RNA and DNA are oxidized and decomposed too much and the synthesis is reduced, a large number of DNA and RNA fragments will be produced, that is, more purine will be produced. When the cell is oxidized, the DNA will be damaged first. Therefore, the older people are, the more purine will be produced and the higher the proportion of gout will be.

Increased purine metabolism: such as chronic hemolytic anemia, rhabdomyolysis, polycythemia, myeloproliferative diseases and chemotherapy or radiotherapy will produce high blood uric acid. Excessive exercise, epileptic state, glycogen storage disease type III, V, VII, can accelerate the degradation of muscle ATP. Myocardial infarction, smoking and acute respiratory failure are also related to the accelerated degradation of apt.

matters needing attention

For patients in daily life, should timely correct bad habits, in the diet to eat some fresh fruits and vegetables is better, reduce exogenous uric acid: reduce the intake of high purine food, this can reduce 20% of uric acid, promote the excretion of uric acid: such as moderately alkaline urine (baking soda, or hot and dry noodles, etc.), promote the excretion of uric acid Drugs such as benzbromarone.