Symptoms of myxedema

summary

Systemic myxedema is a metabolic disorder characterized by scattered or diffuse mucin deposition in the skin and microscopic collagen fragmentation. Mucin exists in the matrix, which is composed of proteoglycans and glucosamine polysaccharides. These acidic mucopolysaccharides produced by fibroblasts have strong hygroscopicity, and can combine with 1000 times of its own volume of water. It is very important to maintain the moisture of dermis, and maintain the volume and texture of dermis. Symptoms of myxedema? Let's talk about it

Symptoms of myxedema

Symptoms of cretinism occur within a few weeks after birth. Performance for low basal metabolic rate, less activity, fear of cold, loss of appetite, slow response, body temperature below normal. Physical retardation, uneven short stature, mental retardation, wide eyelids, widened distance between eyes, collapsed and flat bridge of nose, thick lips, large tongue, swollen eyelids, thick and brittle hair, waxy skin, dry desquamation, non depressed edema, short neck, abdominal expansion, thick and short limbs, decreased muscle tension, hoarse crying.

The clinical manifestations of myxedema vary with the age of onset. The incidence of children's disease is similar to that of children's disease. In older children or adolescence, mucoedema is similar to adult mucoedema, but accompanied by different degrees of growth retardation.

Adult myxedema is characterized by reduced sweating, fear of cold, fatigue, poor appetite, weight gain, mental retardation, hypothermia, indifferent facial expression, edema of cheeks and eyelids, pale and anemia, ivory skin, dry and rough, desquamation and thickening, especially in arms and thighs, non depressed myxedema, sparse and thin shedding of lateral eyebrows, and shedding of armpit and pubic hair, Nails grow slowly, brittle and see vertical and horizontal stripes, teeth are sparse and fragile, muscle relaxation and weakness can appear, bradycardia, heart enlargement, pericardial effusion, serious cases can cause coma.

matters needing attention

Triamcinolone acetonide (triamcinolone acetonide) was injected into the lesion. Triamcinolone acetonide suspension was diluted to 5mg / ml with normal saline. 1ml of triamcinolone acetonide was injected into each part of the lesion. The total amount of triamcinolone acetonide was not more than 40mg, once every 3-4 weeks; It is also suggested that injection of triamcinolone acetonide suspension and equal amount of hyaluronidase (1 500 U / ml normal saline) into the lesion can make the lesion completely subside, but it often recurres after several months of drug withdrawal, and this therapy is still effective in recurrent cases.