How does purpura return a responsibility

summary

Some time ago, I found some small blood spots in my body. I didn't pay much attention to them at that time. I thought they were abrasions or skin allergies caused by dry heat. Later, there were more and more blood spots and the color became darker. So I went to the clinic to see a doctor. The doctor said it was a symptom of purpura. After treatment, now basically recovered, how about purpura, now share with you.

How does purpura return a responsibility

Reason 1: infection factors, the most common bacterial infection is beta hemolytic streptococcus, followed by Staphylococcus aureus, Mycobacterium tuberculosis, Salmonella typhi, pneumococcus and Pseudomonas, etc., upper respiratory tract inflammation is more common, also seen in pneumonia, tonsillitis, scarlet fever, bacillary dysentery, urinary tract infection, pustules, tuberculosis and focus infection (skin, teeth, mouth, middle ear), etc Virus infections include rubella, influenza, measles, chickenpox, mumps, hepatitis, etc. parasitic infections can also cause the disease. Ascaris lumbricoides infection is more common, and hookworm, whipworm, tapeworm, Schistosoma, vaginal Trichomonas, Plasmodium infection, etc.

The second reason is the rapid type allergic reaction. After the allergen enters the body, it combines with the protein in the body to form antigen. After a certain incubation period (5-20 days), the antigen stimulates the immune tissue and plasma cells to produce IgE. IgE is adsorbed on the mast cells (around blood vessels, stomach cavity and skin) of all organs of the body. When encountering the same antigen stimulation again, the antigen will react with the IgE adsorbed on the mast cells The mast cells can release a series of bioactive substances, such as histamine, 5-th, bradykinin, and hypersensitive slow reaction substance (SRS-A). SRS-A is composed of leukotriene C4 (LTC4) and its metabolites LTE and LTD4. LTC4 is converted to LTD4 under the action of gamma glutamyltranspeptidase, and the latter is converted to LTD4 under the action of diglutaminase Under the action of peptidase, LTE4, a series of bioactive substances, mainly act on smooth muscle, cause arteriole, capillary dilation, permeability increase, tissue, organ bleeding, edema.

The third reason is antigen antibody complex reaction, which is the main pathogenesis. Allergens stimulate plasma cells to produce IgG (also produce IgM and IgA), and the latter combines with the corresponding antigens to form antigen antibody complex. Its small molecule is soluble, which can precipitate in the blood vessel wall or glomerular basement membrane, and activate the complement system to produce C3a, C5a, C5, C6, C7, which can attract neutrophils Granulocytes, the latter phagocytize antigen antibody complexes, release lysosomal enzymes, cause vasculitis, involving the corresponding organs. In another part of immune complexes, antibodies are more than antigens, and the molecular weight of the complexes is large. They are insoluble and precipitated. They are removed by the monocyte macrophage system, and generally do not produce pathological changes.

matters needing attention

Attention should be paid to this disease: skin symptoms of patients with allergic purpura are often the first symptoms of this disease. Purpura is more common in the lower limbs and buttocks, with different sizes and symmetries. Purpura parts can appear itching, should keep the skin clean, prevent abrasions, scratches. If there is ulceration, it should be treated in time to prevent bleeding and infection.