What are the causes of nephrotic syndrome

summary

After the appearance of nephrotic syndrome, if it is not treated well, the situation will become more and more serious. Why do I know so clearly? It is because my grandfather got this disease, and it took a long time for his condition to improve. Now let's popularize the science of the causes of nephrotic syndrome.

What are the causes of nephrotic syndrome

First, nephrotic syndrome (NS) can be caused by a variety of causes, with increased glomerular basement membrane permeability, manifested as a group of clinical symptoms of massive proteinuria, hypoproteinemia, high edema, hyperlipidemia. Common symptoms: proteinuria, hypoproteinemia, high edema, hyperlipidemia, etc.

Second, massive proteinuria is the most important clinical manifestation of NS patients, and it is also the most basic pathophysiological mechanism of nephrotic syndrome. Massive proteinuria refers to adult urinary protein excretion > 3.5g/d. Under normal physiological conditions, glomerular filtration membrane has molecular barrier and charge barrier.

Third: the increase of protein content in urine, when far more than the amount of proximal convoluted tubule absorption, the formation of a large number of proteinuria. On this basis, factors that increase glomerular pressure and lead to hyperperfusion and hyperfiltration (such as hypertension, high protein diet or massive infusion of plasma protein) can aggravate the excretion of urinary protein.

matters needing attention

Got nephrotic syndrome, the most obvious symptom may be edema, including the skin of the whole body will appear serious edema, so once there is nephropathy, if edema occurs again, you may need to go to these aspects of doubt, do not delay the treatment.