What are the functions of atropine?

summary

These alkaloids include atropine, scopolamine, anisodamine and anisodine, among which the most important are atropine and scopolamine. Atropine was isolated from belladonna in 1831. Since then, atropine has been found to block the effect of vagus nerve on heart and inhibit salivary secretion. Atropine, scopolamine and anisodamine can be extracted from plants. The natural alkaloid is unstable l-anisodamine, and the stable Raceanisodamine, atropine, can be obtained in the extraction process. The effects of atropine are extensive and complex

What are the functions of atropine?

1. Relaxation of smooth muscle: the effect of atropine on smooth muscle varies with dosage, animal species, tissues and organs. Generally speaking, atropine has little effect on normal smooth muscle, but when the smooth muscle is over excited or in spasmodic state, it has obvious relaxation effect on it, has weak effect on bile duct and bronchus, and has little effect on uterus.

2. Mydriasis: atropine can act on the cholinergic innervated sphincter of pupil and ciliary muscle, showing mydriasis, hypertension and dysopia. Pupil dilation is due to the relaxation of the iris sphincter, the expansion of the iris to the outer edge, which oppresses the anterior chamber space and prevents aqueous humor from flowing into the scleral venous sinus, causing aqueous humor accumulation and intraocular pressure rise; Dysopia is caused by paralysis of the ciliary muscle.

3. Inhibition of gland secretion: atropine can inhibit the secretion of salivary gland, bronchial gland, gastric gland and intestinal gland, etc. after medication, it can cause dry mouth and reduced secretion of respiratory tract (sometimes cough). The inhibition of sweat gland secretion varies with different animal species. For example, the nerves innervating sweat glands in horses and sheep are adrenergic, so there is no effect. It has no effect on milk secretion.

matters needing attention

Atropine has many side effects, and many people can't use it. People allergic to belladonna alkaloids should not use this product. Pregnant women should also be careful to use, can not use intravenous injection, will lead to fetal heartbeat. The use of this product during lactation will cause the drug to be secreted into the milk and consumed by the baby.