What does the harm that albuminuria of pregnant woman tall have

Update Date: 2023-03-11 Source: Network

summary

My wife has been pregnant for more than 4 months, and she has regular physical examination every month. However, when she went to the examination this month, she found urinary protein. The doctor asked her to pay attention to it recently. Let's learn the harm of high urine protein in pregnant women.

What does the harm that albuminuria of pregnant woman tall have

Harm 1: the harm of high protein in urine. First of all, a large amount of proteinuria increases the reabsorption of protein in renal tubules and promotes the production of ammonia. The production of ammonia in renal tissue also plays a certain role in progressive interstitial lesions. In addition, the reabsorption and digestion of a large amount of protein require additional energy, which can cause tubular cell hypoxia.

Harm 2: urine protein has toxic effect on glomerular mesangial cells. After patients enter renal failure, there will be a large number of plasma protein deposition in glomerular mesangial area. The deposition of these macromolecular substances in mesangial area can cause mesangial cell damage, mesangial cell proliferation and mesangial matrix formation increase, leading to glomerulosclerosis.

Harm 3: urinary protein can damage renal tubulointerstitium. A small amount of small molecular protein filtered by normal glomerulus is reabsorbed by proximal tubular epithelial cells and decomposed in lysosome. Under pathological condition, glomerular permeability increases, resulting in a large amount of plasma protein leaking into renal tubule lumen, while proximal tubular epithelial cells reabsorb albumin, resulting in increased lysosomal activity in cytoplasm It can cause cell damage.

matters needing attention

If there is a high level of urinary protein, it does not only mean that the material of the body has been lost, but also the signal of kidney injury. Patients should pay attention to it, recognize the harm of high urinary protein as soon as possible, and actively go to the hospital for treatment.