Is Zoe's syndrome cancer?

summary

I believe most people are unfamiliar with the term zhuoai syndrome. In fact, another name of the disease is gastrinoma. In other words, it is a cancer disease. Once this disease occurs, patients are most likely to have abdominal pain and diarrhea. Generally speaking, it is a very harmful disease. Is zhuoai syndrome cancer? Let's learn about the disease.

Is Zoe's syndrome cancer?

First, zhuoei syndrome (Z-E syndrome; Gastrinoma) a syndrome caused by gastrinogenic tumors of the pancreas or duodenum and characterized by marked hypergastrinemia, high acid secretion, and peptic ulcer. Sometimes gastrinomas can be located in the splenic hilum, mesentery, stomach, lymph nodes or ovaries. Most patients are multiple, 50% of which are malignant. These tumors are usually small (less than 1 cm in diameter) and grow and spread slowly. They are particularly common in patients with other endocrine disorders, especially in parathyroid glands, followed by pituitary and adrenal glands.

Second: it is also called gastrinoma. It belongs to islet non - tumor β Cell tumor, can secrete a lot of gastrin, and then lead to a lot of gastric acid secretion, so that the upper gastrointestinal tract in a high acid environment, prone to ulcers, half of them are malignant, the best surgical treatment.

Finally, the syndrome is also known as Ellison syndrome, which is derived from G cells. It is a comprehensive disease characterized by digestive tract ulcers. The incidence rate of pancreatic endocrine tumors is only inferior to insulinoma. 60% - 70% of them are malignant, often accompanied by lymph node or liver metastasis. 25% - 30% of patients have other endocrine tumors [multiple endocrine neoplasia type I (Meni)]. Part of the tumors were located outside the pancreas, and the duodenum was the most common site. The disease is caused by gastrinoma of islet D cells. Because the tumor can secrete a large amount of gastrin and stimulate the secretion of gastric acid to increase extremely, it leads to refractory atypical ulcer, easy to hemorrhage and perforation. It is often accompanied by parathyroid gland or pituitary adenoma and its corresponding symptoms. Peptic ulcer is the most common symptom, and has poor response to ulcer drugs, The anastomotic ulcer, bleeding and perforation appeared soon. Diarrhea, drainage like or fat diarrhea, often accompanied by abdominal pain. Multiple endocrine neoplasia syndrome, such as hyperparathyroidism, diabetes, etc.

matters needing attention

Omeprazole, an H +, K + - ATPase inhibitor, can significantly reduce the H + secretion of gastric parietal cells. It can improve symptoms and promote ulcer healing. It is currently the treatment of choice. The initial dose is 60 mg per day, but 30% of patients need a higher dose, especially those with severe reflux esophagitis, previous gastric surgery, multiple endocrine tumors, Patients with large or metastatic tumors need to take omeprazole unless they are treated surgically (there may be 20% of patients with nonfamily Zollinger Ellison syndrome). Somatostatin analogues can also reduce the production of gastric acid and can be used as patients who do not respond to omeprazole