Why Parkinson's disease
summary
Parkinson's disease is a kind of neurological disease. My grandfather has this kind of disease, which can cause body shaking and movement obstruction. Then, why do you get Parkinson's disease? Now let's share what I know with you.
Why Parkinson's disease
The first cause is aging. With the growth of age, especially over 60 years old, all parts and organs of the body will be aging, and the number of dopaminergic neurons in substantia nigra will decrease. However, the prevalence of PD is not high in the elderly over 65 years old. Therefore, aging is only one of the risk factors of PD.
Etiology 2, genetic factors, the role of genetic factors in the pathogenesis of PD more and more attention by scholars. Since the discovery of the first Parkinson's disease pathogenic gene α - synuclein (Park1) in the late 1990s, at least six pathogenic genes have been associated with familial Parkinson's disease. But only 5-10% of Parkinson's disease have family history, most of them are sporadic cases. Genetic factors are only one of the causes of PD.
In the 1980s, American scholars such as Langston found that some drug addicts would quickly develop typical Parkinson's disease like symptoms, and it was effective for levodopa preparations. It is found that the synthetic heroin used by drug addicts contains a neurotoxic substance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The substance is transformed into highly toxic 1-methyl-4-phenyl-pyridine ion MPP + in the brain and selectively enters into the substantia nigra dopaminergic neurons, which inhibits the activity of mitochondrial respiratory chain complex I and promotes oxidative stress response, leading to the degeneration and death of dopaminergic neurons.
matters needing attention
After Parkinson's disease, the emphasis is on treatment, and drug treatment is the most important method. At the same time, the elderly should also prevent such diseases. At ordinary times, they should drink at least three cups of green tea every day, which can effectively reduce the incidence of the disease.
