Stage 0 symptoms of CLL?

summary

Chronic lymphocytic leukemia (CLL) is a clonal malignant disease of B lymphocytes (T lymphocytes are rare). The disease is often painless, accompanied by progressive accumulation of slowly progressing mature small lymphocytes, which are immunodeficient and have a low response to antigenic stimuli. Immune dysfunction is related to abnormal B cells and inappropriate antibody formation, which can inhibit the immune function of the body. The progressive stage of CLL can lead to bone marrow failure and direct infiltration of tissues and organs. Stage 0 symptoms of CLL? Let's talk about it

Stage 0 symptoms of CLL?

Symptoms and signs often appear later than the obvious changes of hemogram. About 90% of the patients are over 50 years old, with an average age of 65 years old. Many patients are found to have lymphocytosis by accident. The earliest symptoms are often fatigue, fatigue and shortness of breath during physical activity. Superficial lymph nodes, especially cervical lymph nodes, often attract the attention of patients first. In the late stage, they are clustered in clusters, with a diameter of 2-3cm, without tenderness, hardness and mobility. Mesenteric or retroperitoneal lymph nodes can cause abdominal or urinary symptoms.

Splenomegaly is mild to moderate, and liver can also be enlarged, but it is not as significant as CML. Later, there were anorexia, emaciation, low fever, night sweats, anemia and other symptoms. About 10% or more patients may have autoimmune hemolytic anemia. At this time, anemia is often severe and jaundice may occur. Late may have skin purpura and bleeding tendency, easy to infection, especially respiratory tract infection. It may be the direct cause of death.

In addition, gastrointestinal tract and skeletal system may be damaged to varying degrees. Some patients have itchy skin. Occasionally, leukemic skin infiltration was seen, which showed purplish red or brownish red nodules or skin thickening. The skin of the whole body is red, tonsil, salivary gland or lacrimal gland can also be enlarged.

matters needing attention

Radiotherapy: mainly used for superficial or deep lymphadenopathy or splenomegaly. If there are compression or obstruction symptoms, local radiotherapy is also needed, and the effect is good. 60Co whole body irradiation can also relieve some patients, but it is rarely used in clinic.