Does normal person have abnormal red blood cell?

summary

In recent years, urine red blood cell morphology examination has been widely used in clinic. The basic principle is that the glomerular derived red blood cells are affected by the mechanical damage of glomerular basement membrane and / or the change of renal osmotic pressure gradient. Do normal people have abnormal red blood cells? Let's talk about my views.

Does normal person have abnormal red blood cell?

First, there are no abnormal red blood cells in normal people. Glomerular filtration has been simulated in vitro with a certain osmotic pressure, pH range and 3? Then the "hematuria suspension" was filtered through the device, and the malformed red blood cells similar to those in renal parenchymal diseases appeared. When the membrane was removed, malformed red blood cells did not appear even under the same osmotic pressure and pH value. Therefore, it is considered that the filtration of glomerular filtration membrane is an important condition for the production of malformed red blood cells.

Second, a series of osmotic pressure changes in renal tubules are important factors for the production of malformed red blood cells. At the moment when the red blood cells leaked from the glomerulus pass through the various parts of the renal tubules, the osmotic pressure environment changes suddenly, and the red blood cells will have hemolytic changes under the low osmotic pressure state. The amount of hemoglobin in the red blood cells varies from normal to shadow red blood cells. The membrane of the red blood cells can rupture, and the components in the red blood cells are discharged out of the cells, and there are spore like processes or vacuoles; Red blood cells are easy to shrink and shrink under hypertonic condition. Urine red blood cells in the renal tubules through the hypotonic, isotonic, hypertonic and other different environments, resulting in cells showing typical pleomorphic characteristics.

Third, the key part of renal tubular function affecting the morphology of urinary red blood cells is the hypotonic area of the ascending branch of renal tubular medullary loop. If the hypotonic area is damaged or the renal tubular function is defective, the production of urinary malformed red blood cells will be affected. Solute tension in urine can affect the morphology of urinary red blood cells. In vitro tests showed that the osmotic pressure of urine solution remained unchanged, but the morphology of red blood cells tended to be normal when the content of sodium chloride increased.

matters needing attention

Water spinach is an alkaline food, and contains potassium, chlorine and other elements to regulate water-liquid balance, which can protect renal function. Pumpkin has the functions of anti-inflammatory, analgesic, detoxification and insecticidal. The lipid substances in pumpkin seeds have a good preventive effect on urinary system diseases.