Which drugs can cause hypoglycemia?

summary

Drug induced hypoglycemia often occurs in patients with diabetes during the use of hypoglycemic drugs, it is a relatively difficult to cure a good disease, when hypoglycemic drug overdose, or drug interaction, or drug-induced hepatorenal toxicity can occur. When combined with liver and kidney diseases, the risk of primary or drug-induced hypoglycemia increased sharply. Many people are not cured for a long time, not because they can't be cured, but because they don't understand. What drugs can cause hypoglycemia?.

Which drugs can cause hypoglycemia?

First, aspirin rarely causes hypoglycemia in healthy people, but when patients with diabetes, especially those with impaired liver and kidney function take aspirin, it will strengthen the role of hypoglycemic drugs. In addition, other NSAIDs have similar effects, such as indomethacin and piroxicam. The mechanism of aspirin lowering blood glucose is still unclear, which may be related to the increase of insulin level induced by aspirin.

Second, cardiovascular drugs β Receptor blockers: in different situations, β Receptor blockers alone or in combination with other drugs can cause hyperglycemia and hypoglycemia. Therefore, it is suggested that diabetic patients are using the β We should be alert when using receptor blockers. ② Acetylcholinesterase inhibitor: can improve insulin resistance and blood glucose control, even with a lower dose of hypoglycemic drugs can also cause hypoglycemia. ③ Antiarrhythmic drugs: such as diisopropylamine (verapamil) and other antiarrhythmic drugs. The hypoglycemia caused by excessive insulin secretion and insufficient reverse regulation can be aggravated when using diisopropylamine alone or in combination with other hypoglycemic drugs. Impaired renal function, old age and malnutrition are the risk factors of diisopropylamine induced hypoglycemia. In addition, sibenzoline has a similar effect. ④ Lipid lowering drugs: abnormal lipid metabolism is one of the causes of insulin resistance. Increased lipolysis and free fatty acid oxidation promote gluconeogenesis and induce insulin resistance by inhibiting glucose uptake in peripheral tissues. In experiments, lipid-lowering drugs that inhibit the formation of free fatty acids, such as acipimox, can enhance insulin sensitivity.

Third: there are a lot of reports about hypoglycemia in patients using certain drugs with other drugs, and this situation often occurs when combined with other drugs or in a certain disease state, especially when the liver and kidney function is damaged. The mechanism of hypoglycemia caused by only a few drugs has been confirmed, such as pentamidine (a drug used to treat Leishmania, trypanosomiasis and Pneumocystis carinii pneumonia) and quinine (an antimalarial drug).

matters needing attention

In many cases (such as trimethoprim sulfaxazole, etc.), it is difficult to prove whether hypoglycemia is caused by drugs or by drug interaction, disease state or completely unrelated to drugs. However, these case reports remind doctors and diabetic patients to pay attention to the sealing of hypoglycemia when using these drugs.