What should be checked for serum like reaction?

summary

Serum disease and serum disease-like reaction are the diseases that appear after the body's serum is abnormal. Patients can diagnose the disease through serum examination, and patients also need to understand the pathogenesis of the disease in their life, so as to prevent the disease. What should the serum like reaction check? Now let me tell you something.

What should be checked for serum like reaction?

When the pathogenic substances containing serum protein enter the body, specific antibodies can be produced in the body after 2-3 weeks. At this time, if the above-mentioned pathogenic substances still exist in the human body, they can form immune complexes with these antibodies in the form of antigen or hapten and deposit on the vascular bed, and activate the classical pathway of complement, resulting in a series of inflammatory reactions, serum diseases and serum disease-like reactions.

After the first time receiving heterologous serum or non protein drugs, the symptoms may not appear, because the body still has enough antibodies to form immune complexes with foreign antigens and be eliminated in vitro. However, after receiving the same antigen again, some sensitized B lymphocytes will rapidly transform into plasma cells, secrete a large number of antibodies and combine with the antigen to form immune complexes, causing rapid serum reaction.

The histopathological changes of this disease are similar to those of type III allergic diseases, such as rheumatic fever and nodular polyarteritis, but the degree is mild. The characteristic pathological changes included small vessel dilatation, granulocyte infiltration and edema, and the cell infiltration was mainly lymphocyte, neutrophil and eosinophil infiltration; The pathological changes of the kidney were severe, including focal ischemia and Fibrinosis.

matters needing attention

The pathogenesis of serum disease and serum disease-like reaction is related to many factors. In the early stage of the disease, the symptoms are less, and it is difficult for patients to find the disease. However, with the development of the disease, the symptoms of the body will increase, and the damage to patients is very serious. At this time, the disease can be diagnosed by examination.