Globulin is on the high side, white globulin is on the low side how to return a responsibility

summary

Globulin is one of the common detection indexes in liver function examination, many people have the phenomenon of high globulin in the examination. So, what is the reason of high globulin and low white globulin ratio?

Globulin is on the high side, white globulin is on the low side how to return a responsibility

First, the reason of high globulin and low white globulin ratio is that α - globulin is produced by hepatocytes. When the hepatocytes are necrotic in the liver, α - globulin will rise; γ - globulin is produced by the human immune system. The longer the course of disease, the more severe the disease, the higher the globulin. In chronic hepatitis, α - globulin and γ - globulin are increased, and the increase of γ - globulin is the main. In fact, when chronic inflammation occurs in the liver, there are bacteria or viruses in the body. The antigens produced by these pathogens can stimulate lymphocytes. When lymphocytes are activated, they can produce more antibodies. Because the antibody is produced by globulin, the reason for the high level of globulin lies here.

Second, the reason for the low white globular ratio. For patients with liver diseases, the low white globular ratio is mostly caused by liver damage. Especially for patients with severe chronic hepatitis, liver cirrhosis, liver cancer and other severe hepatitis, if the liver is seriously damaged, albumin will be reduced. At this time, if the body's immune system is activated to fight against hepatitis B virus, Globulin will increase, which will lead to a low white globulin ratio.

Third: what is the white globulin ratio? In the liver function examination, the white globulin ratio often encountered refers to the ratio of plasma albumin (ALB) and globulin (GLB), which is often written as a / g.

matters needing attention

Low WBR is generally caused by liver inflammation, so once patients find the disease, they must go to the hospital for HBV-DNA, liver function and liver fiber examination as soon as possible. To understand the number of virus, replication and liver damage in detail, and then combined with the patient's past medical history to develop targeted treatment.