What is irritable bowel syndrome?

summary

Irritable bowel syndrome is a disease that sounds very dangerous. If patients feel unwell, they have to go to the hospital immediately for diagnosis and treatment. This is the most common functional intestinal disease. Almost one out of ten people in China is a patient. However, the impact of the disease on life is not too great. Although it is not serious, we also need treatment, Let me learn about irritable bowel syndrome with you today?.

What is irritable bowel syndrome?

First, intestinal bacterial overgrowth (SIBO) is characterized by abnormal overgrowth of bacteria in the small intestine. One study showed that 84% of IBS patients had Sibo, and IBS patients were 26 times more likely to have Sibo than healthy controls. The results about the correlation between Sibo and IBS are unclear. This may be partly because there is no consistent gold standard for the detection of Sibo, which makes the methods used to detect Sibo different. However, there is evidence that Sibo is a predisposing factor in some IBS patients. Antibiotics used to treat Sibo, such as rifaximin and neomycin, are effective in patients with IBS. For example, in a randomized controlled trial, IBS patients treated with rifaximin for 10 days were able to recover symptoms for up to 10 weeks. A recent meta-analysis of five studies found that rifaximin improved all symptoms of IBS and reduced abdominal distension more effectively than the control group.

Second: Dysbiosis. The human gut microbiota is a very complex structure, including more than 100 trillion microorganisms. These gut microbes affect our physiology, metabolism, nutrition and immune function. Dysbacteriosis is associated with gastrointestinal problems, such as IBS and inflammatory bowel disease; At the same time, dysbacteriosis is associated with many parenteral diseases, including diabetes and obesity. The study found that 83% of IBS patients had abnormal fecal biomarkers, and 73% of IBS patients had intestinal flora imbalance. Many studies have shown that probiotics and prebiotics, which are used to regulate the flora, can have a certain effect on IBS. In addition, a low FODMAP diet (limiting certain carbohydrates that can feed intestinal bacteria) can play a role in IBS.

Third: increased intestinal permeability (also known as leaky gut) one of the most important functions of the digestive tract is to act as a barrier to prevent pathogens and undigested food particles from entering the internal environment. Many studies have found that IBS is associated with increased intestinal permeability, in which a cytokine called interleukin-22 is involved. Interleukin-22 affects intestinal permeability. It is worth mentioning that the increase of intestinal permeability is an organic change, which indicates that IBS is not always dysfunctional.

matters needing attention

To say more, the disease has a great relationship with mentality. Even if a person with a good mentality suffers from the disease, as long as his mentality remains normal and he develops a good eating habit in his daily life, even if he does not go to see a doctor, there is no problem.