How to treat kidney transplantation with BK virus?

Update Date: 2024-01-17 Source: Network

summary

After renal transplantation, patients are most worried about the graft dysfunction. In addition to rejection and drug toxicity, virus infection is also an important cause of renal allograft dysfunction. Among them, "BK virus" is a kind of virus that mainly invades the transplanted kidney. It usually "hides" in the human body and "attacks" the kidney mercilessly "once" the time is ripe ". How to treat kidney transplantation with BK virus? What about it? Let's take a look at it.

How to treat kidney transplantation with BK virus?

First, the existence of "BK virus" is very widespread, 60-80% of the general population can detect antibodies to "BK virus". In adults with normal immunity, "BK virus" is not pathogenic, but "latent" in the human body, especially in the epithelial cells of urinary system. When the human immunity is significantly reduced, such as kidney transplantation or HIV infection, then the "BK virus" will be reactivated and take the opportunity to "make waves".

Second: after kidney transplantation, about 5% of the patients will have "BK virus" infection, the main site of infection is the transplanted kidney and ureter, the time of infection is mainly in the first year after kidney transplantation.

Third, "BK virus" infection mainly causes transplanted kidney viral nephropathy. Once infection occurs, about 30-65% of the patients will lose function of the transplanted kidney. Proteinuria is usually not obvious, and sometimes it will cause ureteral stenosis of the transplanted kidney, leading to hydronephrosis of the transplanted kidney. Some patients will also have hemorrhagic cystitis.

matters needing attention

Once the "BK virus" infection occurs, the immune system of the patient's resistance to the virus decreased significantly. At this time, the primary task is to improve the immunity of patients, and the main method is to reduce the use of immunosuppressants, especially the use of FK506 and mycophenolate, which is the main method to reduce the replication of "BK virus".