What is the cause of brittle bone disease

summary

For brittle bone disease, I believe many people will recognize that osteogenesis imperfecta can also be called brittle bone disease. It is a rare congenital bone developmental disorder. The cause of this disease is not only the genetic problem, but also genetic and other factors can cause osteogenesis imperfecta. Men and women in the risk of disease is similar, it is generally divided into two types of congenital and late-onset, congenital osteogenesis imperfecta patients are generally due to genetic reasons, but now the cause of the disease is not very clear, gene mutation may also lead to osteogenesis imperfecta patients.

What is the cause of brittle bone disease

First: the cause of osteogenesis imperfecta may be the gene mutation of the patient, but it can not be classified as a genetic disease. Osteogenesis imperfecta and congenital inheritance can also cause diseases. In current medicine, the cause of osteogenesis imperfecta is not very clear.

Second: 30% of the patients with osteogenesis imperfecta are caused by congenital inheritance. These patients generally have a family history. The patients with congenital imperfecta usually become stillborn during pregnancy or die soon after birth, while the patients with delayed onset can survive for a long time before onset.

Third: another cause of osteogenesis imperfecta is the dysplasia of collagen, the main component of bone and bone tissue. The patient's collagen tissue contains too much proline. When the patient takes oral proline, the peak of blood proline is lower than that of normal children. So this disease is not a genetic disease.

matters needing attention

The cause of osteogenesis imperfecta is not very clear, this disease is a congenital genetic disease, with genetic characteristics, if both parents are sick, children will have the possibility of disease, so the patient's family want a baby, it is necessary to do a good job in pregnancy examination, always pay attention to the baby's health.