What harm does hyperprolactinemia have?

summary

Of course, the risk of hyperprolactinemia is not small, and the serum prolactin (PRL) more than 1.14nmol/l or 25ug / L is called hyperprolactinemia. Because prolactin is a stress hormone, the hormone level fluctuates greatly within 24 hours, so the diagnosis can be made only after two reexamination. Prolactinoma is the most common cause of hyperprolactinemia. Other intracranial tumors or hypothyroidism, renal insufficiency, polycystic ovary syndrome can also cause hyperprolactinemia. Let's talk about the harm of hyperprolactinemia?.

What harm does hyperprolactinemia have?

First, about 80% of the patients with menstrual disorder show irregular menstruation, and 70% of the patients show galactorrhea. High level prolactin acts on hypothalamus to inhibit the secretion of pituitary follicle stimulating hormone (FSH) and luteinizing hormone (LH), reduce or interfere with secretion rhythm, and affect menstrual cycle.

Second, excessive prolactin inhibits the secretion of FSH and LH in infertile women, resulting in the failure of FSH and LH secretion peak in the middle of menstruation, abnormal ovarian follicle development and ovulation disorder; Men can cause oligospermia and infertility.

Third: early pregnancy abortion patients with hyperprolactinemia can also inhibit the production of progesterone by granulosa cells due to higher prolactin level after ovulation, leading to luteal insufficiency and increasing the risk of early abortion.

matters needing attention

Patients with fertility requirements should be treated with drugs and try to get pregnant again after PRL level is stable for a period of time. For patients with prolactin macroadenoma, especially those who are still infertile, they should actively enter the professional hospital for surgical treatment, and actively prepare for pregnancy after the use of drug treatment to stabilize the PRL level. The ovulation inducing drugs can be used to promote ovulation under the supervision of the reproductive doctor if the simple drug treatment can not successfully ovulate pregnancy.