Causes of low creatinine

summary

What is the reason of low creatinine? Creatinine (CR) is the product of muscle metabolism in human body. Every 20g muscle metabolism can produce 1mg creatinine. Creatinine is mainly excreted by glomerular filtration. Serum creatinine comes from both exogenous and endogenous sources. Exogenous creatinine is the product of meat metabolism in the body; endogenous creatinine is the product of muscle metabolism in the body. When the intake of meat food is stable, the body's muscle metabolism does not change greatly, and the production of creatinine will be relatively constant. What is the reason of low creatinine

Causes of low creatinine

first. Creatinine is higher than normal, which includes serum creatinine and urine creatinine, but serum creatinine is more significant to measure renal function. So high creatinine generally refers to high blood creatinine. The normal value of serum creatinine is different in different hospitals. Generally speaking, the normal value of serum creatinine is 44-133umol / L.

Secondly, when the serum creatinine value is high, it indicates that the patient's renal function has problems, the ability of renal metabolic waste is decreased, and some harmful toxins in the body can not be discharged from the body normally. What about the opposite? The reason of low serum creatinine is that after the kidney is invaded by various causes, it forms pathological changes, stimulates the fibroblasts in the kidney to transform into myofibroblasts, and at the same time invades and stimulates the inherent normal renal tissue, causing the same pathological changes.

Then, at this time, it entered the organic damage stage (i.e. renal function damage stage). At this time, due to the continuous damage of the kidney, the function of excreting waste decreased, resulting in the accumulation of creatinine and other mycotoxins in the body, resulting in the increase of blood creatinine and urea nitrogen, the decrease of urine creatinine, and the decrease of double kidney filtration. At the same time, patients will have high blood pressure, high edema and other physical symptoms.

matters needing attention

There is no clinical significance when the creatinine is low. There is no need to worry about it. The creatinine in the human body is mainly produced by creatine metabolized by muscles, which is excreted to the body through the kidney. In general, because the body's muscle mass is relatively stable, the production of creatinine is also constant. The level of serum creatinine mainly depends on the amount of creatinine excreted by the liver, If both kidneys are normal, then as long as one kidney functions, serum creatinine can be maintained at a normal level. That is to say, if the degree of kidney damage is more than half, serum creatinine will rise. Is the cause of low creatinine clear.