Inventory: why gout

summary

With the progress of society, the living standard of contemporary people has been greatly improved. However, there are more and more gout patients around our daily life. Why do people in our life get gout? I will sort out some reasons for gout as follows:

Inventory: why gout

Reason 1: gout induced by improper diet is an important cause of gout, gout dietary nutrition therapy is to prevent or reduce the acute attack of gout, so as to avoid the extension of acute attack of gout. The purpose is to reduce the deposition of urate in the body, prevent the formation of uric acid stones, reduce the use of anti uric acid drugs, and ultimately reduce its side effects.

The second reason is that the long-term increase of uric acid in blood is a key cause of gout. Human uric acid mainly comes from two aspects: (1) endogenous uric acid is produced by the action of some enzymes from proteins in human cells, nucleic acids and other purine compounds produced by catabolism. (2) purine compounds, nucleic acids and nucleoproteins in food are digested and absorbed to produce exogenous uric acid through the action of some enzymes. 　

The third reason is that the mechanism of gout is the decrease of uric acid decomposition, which has been excluded as the mechanism of hyperuricemia. In addition, some of the causes of hyperuricemia are caused by the deficiency of hypoxanthine guanine phosphoribosyl transferase (HGPRT). When the enzyme is abnormal, PRPP increases, purine synthesis increases and uric acid production increases. In addition, any process leading to the acceleration of intracellular adenylate decomposition will lead to the increase of uric acid production due to the acceleration of purine degradation, resulting in hyperuricemia.

matters needing attention

This disease is a recurrent, acute or chronic arthritis of the peripheral joints. It is caused by the deposition of monosodium urate crystals in and around the joints and tendons.