Neonatal tyrosine high reason?

summary

The development of normal children's large movement has certain regularity. For example, when children are about 11 months old, they can hold the railings and stand alone; when they are 13-15 months old, they can walk alone; when they are 1.5 years old, they can walk with a toy car; when they are about 2 years old, they can walk steadily. However, it is normal for each child to have a slight difference in their development. For example, in winter, they wear too much clothes, are inconvenient to walk, and the time of walking alone is delayed; Just learn to speak, neonatal tyrosine high reason? Let's talk about it

Neonatal tyrosine high reason?

A congenital disorder of amino acid metabolism characterized by a lack of phenylalanine hydroxylase activity, resulting in an increase in plasma phenylalanine concentration, often resulting in severe mental retardation. Phenylketonuria (PKU) was found in the majority of the population, but it was rare in German Jews and blacks. The incidence rate in the United States is 1/16000 live birth infants. The typical phenylketonuria is autosomal recessive.

Phenylalanine is one of the essential amino acids. Under normal conditions, if the body excessive, hydroxylation to tyrosine and excluded, the reaction requires the participation of phenylalanine hydroxylase. If the enzyme is inactive, phenylalanine accumulates in the blood and is excreted mainly in urine; Some phenylalanine is converted into Phenylpyruvate by transamination, and the latter is further metabolized into phenylacetic acid, phenyllactic acid and n-hydroxyphenylacetic acid, which are excreted from urine.

Neonatal period often asymptomatic, occasionally, the baby has drowsiness or feeding difficulties. Mental retardation is the most important manifestation, generally severe, mainly occurs in untreated patients. The child's hair, skin and eyes are lighter than those of his family members. Some children may develop infantile eczema like rashes.

matters needing attention

Drink less and more water. All kinds of drinks, such as soda, juice, cola, contain more sugar and electrolytes. Excessive intake can affect appetite and digestive function. When children sweat more after exercise, it is best to drink more boiled water to supplement water. Don't eat too cold. In summer, there are many kinds of fruits and vegetables. Parents often make some refreshing cold dishes. If they unintentionally make their children eat too many raw cold fruits and vegetables, it can lead to digestive dysfunction, vomiting, diarrhea and so on.