What examination does Parkinson's disease do
summary
My grandfather's limbs were shaking severely for some time. At that time, his family was very worried about Parkinson's disease. However, some diseases would have similar manifestations. They rushed to the best hospital in the city for examination and were diagnosed. Let's take a look at what tests Parkinson's disease does.
What examination does Parkinson's disease do
One: imaging examination: Parkinson's disease is a degenerative disease of the central nervous system, through CT, MRI imaging examination can more clearly understand the development of Parkinson's disease. The pathological changes of Parkinson's disease are mainly in substantia nigra, striatum, globus pallidus, caudate nucleus and cerebral cortex. Therefore, in addition to general brain atrophy, basal ganglia calcification can sometimes be seen on CT images. In addition to ventriculomegaly and other signs of brain atrophy on MRI, multiple hyperintense spots were often found in basal ganglia and white matter on T2 weighted images.
Second: SPECT imaging: clinically, the etiology of Parkinson's disease is complex, and the symptoms are diverse. The examination of dopamine receptor (DAR) functional imaging is very helpful for a faster and more accurate understanding of the patient's condition. Dopamine receptors are widely distributed in the dopaminergic pathway of the central nervous system, mainly in the substantia nigra and striatum. Dar (DL) is located in the soma of non cholinergic interneurons in the striatum; Dar (D2) is located in the soma of dopaminergic neurons in the substantia nigra and striatum.
The third: laboratory examination: (1) the serum renin activity and tyrosine content decreased; the content of NE and 5-HT in substantia nigra and striatum decreased, and the activity of glutamic acid decarboxylase (GAD) decreased by 50% compared with the control group. (2) The contents of GABA and HVA in CSF decreased significantly. (3) Biochemical test and radioimmunoassay showed that the content of somatostatin in CSF decreased. Urinary DA and its metabolites 3-methoxytyramine, 5-HT and renal a-glandulin, NE also decreased.
matters needing attention
If it's difficult to sit down or stand up again, choose a straight chair with armrest. Don't use too deep and soft chair and sofa. Encourage early patients to do more active exercise, try to continue to work, cultivate hobbies.
