Multiple endocrine adenoma type Ⅱ in children?

summary

Multiple endocrine adenoma syndrome is a group of dominant hereditary diseases with obvious familial tendency. Multiple endocrine glands have tumors, and can produce a variety of hormones or hormone like substances that are the same as the glands in which they are located? Let's talk about it

Multiple endocrine adenoma type Ⅱ in children?

Medullary thyroid carcinoma (MTC): 80% ～ 92% of MTC is a tumor originated from C cells of thyroid gland. In addition to the enlargement of thyroid gland which is consistent with the characteristics of cancer, many clinical syndromes will be caused by the secretion of calcitonin and a variety of heterologous hormones (ACTH, VIP, 5-HT, etc.): peptic ulcer, diarrhea, skin flushing, hypertension, but serum calcium is not low or even high; The level of serum calcitonin was measured.

Pheochromocytoma: 70% - 80%, mostly bilateral adrenal medulla, different from sporadic pheochromocytoma, mainly secreting adrenaline, 70% familial, 10% asymptomatic, 90% pheochromocytoma clinical features, a few accompanied with neurofibromatosis and cerebellum optic reticulum syndrome.

Hyperparathyroidism (hyperplasia or adenoma): 50%, manifested as hypercalcemia. In clinical practice, the main manifestation is a certain gland lesion, which conceals the manifestation of other endocrine gland tumors. Therefore, when finding an endocrine adenoma, the possibility of this syndrome should also be considered.

matters needing attention

Pregnant women should avoid harmful factors as far as possible, including smoke, alcohol, drugs, radiation, pesticides, noise, volatile harmful gases, toxic and harmful heavy metals, etc,