Glioblastoma multiforme?

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Glioblastoma multiforme? Glioblastoma, also known as glioblastoma, is a common malignant neuroepithelial tumor of the central nervous system in adults, accounting for 22.3% of neuroepithelial tumors and 10.2% of intracranial tumors.

Glioblastoma multiforme?

GBM is the most malignant type of astrocytoma. GBM is generally considered to be a progressive anaplastic manifestation of astrocytoma, mixed astrooligodendrocytoma and oligodendroglioma. It is a grade IV differentiated astrocytoma. The duration of this change varies, but it may be quite short. Glioblastoma with well differentiated components is called secondary glioblastoma, and glioblastoma without well differentiated components is called primary glioblastoma.

Primary GBM can be derived from gliomas that grow too fast and well differentiated, or from denovo primary tumors with astrocyte and oligodendrocyte differentiation tendency. The rare variant GBM can be divided into three types: giant cell glioblastoma, lipid rich epithelioid glioblastoma and gliosarcoma.

Most of the clinical manifestations were headache, convulsions and mental symptoms. The tumor grew rapidly and was highly malignant. The disease progressed rapidly. The average survival time was about 12 months. The cytological features of GBM are obvious necrosis in the tumor tissue, palisade like arrangement of tumor cells around, obvious proliferation of small blood vessels in the stroma, flower bud like, glomerular like, or curved long band. Tumor cells are often pleomorphic, and heteromorphic multinucleated giant cells are easy to be seen. It is often called pleomorphic glioblastoma.

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The growth characteristics of GBM are as follows: 1) it can extend to the depth along the nerve tracts in the white matter, for example, frontal lobe tumors can grow to ipsilateral parietal lobe along the frontoparietal tract, ipsilateral temporal lobe along the uncinate tract, and even to the contralateral cerebral hemisphere along the corpus callosum; ② Multicentric growth, 4.9% - 20% of GBM is composed of several seemingly independent tumor centers, each tumor center often gathered together, sometimes satellite focus can be seen near the main body of the tumor.