How does methotrexate treat rheumatoid disease to return a responsibility

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Methotrexate treatment of rheumatoid arthritis, rheumatoid arthritis is a chronic erosive arthritis characterized by systemic autoimmune disease. Rheumatoid arthritis is characterized by synovitis and the destruction of articular cartilage and bone, which eventually leads to joint deformity. The author says next methotrexate treats rheumatoid how to return a responsibility

How does methotrexate treat rheumatoid disease to return a responsibility

First of all, rheumatoid arthritis is a systemic autoimmune disease characterized by chronic erosive arthritis. Rheumatoid arthritis is characterized by synovitis and the destruction of articular cartilage and bone, which eventually leads to joint deformity. At present, there are many methods for the treatment of rheumatoid arthritis, emphasizing the treatment principles of early, combined and individualized treatment. Methotrexate tablets combined with leflunomide in the treatment of rheumatoid arthritis has achieved good clinical effect.

Secondly, low-dose methotrexate pulse therapy is the most widely used drug in the treatment of rheumatoid arthritis, which has definite curative effect, good tolerance and satisfactory benefit / toxicity. It mainly suppresses the activation of immune cells by interfering with folic acid metabolism. The most common side effects are bone marrow suppression and mucositis, followed by abnormal liver function and occasional hypersensitivity.

Finally, methotrexate can inhibit the synthesis of purine by inhibiting dihydrofolate reductase, so as to inhibit the synthesis of thymine, reduce the chemotaxis of neutrophils, inhibit the release of inflammatory cytokines, so as to play a role in alleviating symptoms and improving bone destruction. Combined with MTX, MTX 1-2mg / day is the most common side effects, such as headache, alopecia and so on.

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Methotrexate in the treatment of rheumatoid arthritis how to return a responsibility, methotrexate in the world has become the preferred drug for the treatment of rheumatoid arthritis, clinical research results show that methotrexate tablets combined with leflunomide in the treatment of rheumatoid arthritis effect is obvious, after treatment, the indicators are significantly improved, and its price is low. However, methotrexate is a cytotoxic drug with immunosuppressive effect and obvious side effects. Patients need to use it under the guidance of doctors.