How does child get hepatoblastoma to cause?

summary

Hepatoblastoma in children is a malignant tumor of the liver, which is caused by the embryonic tissue of the liver. Most of them were born in infants under 3 years old. The clinical features are abdominal enlargement, palpable mass in upper abdomen, anorexia, emaciation and anemia. Jaundice and ascites were found in the late stage. The diagnosis was made according to the clinical manifestations, laboratory and auxiliary examination results. If the tumor is single, small, superficial and without extrahepatic metastasis, surgical resection can be cured. How does child get hepatoblastoma to cause?

How does child get hepatoblastoma to cause?

At the beginning of the disease, the general symptoms are not obvious, no jaundice or fever. But the abdomen is full, I was found by my parents. Sometimes the doctor found the abdominal mass during the health examination. Older children may complain of abdominal pain. Sometimes the liver cancer cells can produce gonadotropin, which makes the children have precocious puberty. Pigmentation was found in some cases. Some children do not feel abdominal pain. The course of disease is faster than that of common malignant tumors. Can have anorexia, fatigue, progressive weight loss. Later stage may have fever, secondary anemia, ascites and lower extremity edema. Occasionally, upper gastrointestinal bleeding and jaundice were seen. The liver is large and hard, the edge of liver is obviously hard, the surface is not smooth and there are nodules.

The detection of serum alpha fetoprotein is very important for the diagnosis of liver cancer. 90% - 100% of the cases were positive, which was higher than that in adults (70% - 80% in adults). Many biochemical substances such as protein, lipid and enzyme are produced by the liver or metabolized in the liver. Therefore, it is necessary that the examination of blood cholesterol, lactate dehydrogenase (LDH), albumin, globulin, alkaline phosphatase and bilirubin can reflect the liver function. Serum alkaline phosphatase is often increased, which is helpful for the diagnosis of liver cancer. Ultrasonic examination and radionuclide liver scan are helpful for the diagnosis of this disease. CT, MRI (magnetic resonance imaging diagnosis) have reference value for diagnosis.

The exact cause is unknown. The case reported that the onset of Hb was related to fetal alcoholism or mother's oral contraceptives. Other scholars believe that its pathogenesis may be related to homozygous variation of 11p allele. The diagnosis was made according to the clinical manifestations, laboratory and auxiliary examination results. If the tumor is single, small, superficial and without extrahepatic metastasis, surgical resection can be cured.

matters needing attention

Hepatoblastoma is the most common liver tumor in children, accounting for 62% of primary liver malignant tumors in children. The disease originated from embryonic primordial cells of the liver, which is a malignant tumor of the liver derived from epithelium. Many cases that were previously considered unresectable can now be treated surgically by preoperative chemotherapy and interventional therapy to make the tumor smaller and the normal liver larger. Patients with hepatoblastoma should pay attention to supplement enough high-quality protein in diet. The best animal protein is chicken, fish and milk. The best plant protein is beans. Ginseng, American ginseng, astragalus, red jujube, diet fish, turtle and longan can be used to promote cell proliferation.