Is autoimmune gastritis rare?

summary

The stomach is a very important organ in our body. If we want to have a healthy body, we must have a healthy stomach. If there is a problem in our stomach, it will not only bring us pain, but also easily affect our digestion. Autoimmune gastritis is one of the stomach diseases, Many friends may not know much about autoimmune gastritis. Let's talk about the rare autoimmune gastritis?

Is autoimmune gastritis rare?

The pathological manifestations of autoimmune gastritis were diffuse atrophy of gastric body and fundus, while the antral mucosa was normal. All kinds of endogenous or exogenous harmful factors can cause gastric mucosal injury, release parietal cell antigen, and sensitize immune cells to cause immune response, resulting in chronic inflammation of gastric mucosa, and then produce anti parietal cell antibody through humoral immunity.

The target organ of anti parietal cell antibody is H + - K + - ATPase α and β Because the glands and parietal cells of the stomach were broken, the gastric acid secretion function was significantly reduced or no acid was found, and the serum gastrin level was increased by feedback. The destruction of the main cell can lead to the decrease of pepsinogen I. Gastric acid deficiency affects iron absorption, leading to iron deficiency anemia. Gastrin can promote the proliferation of chromaffin cells, increase the level of chromaffin a, and may develop into gastric carcinoid.

Atrophy of gastric fundus and body, intestinal metaplasia or atypical hyperplasia, and increased incidence of gastric adenocarcinoma. Some patients can detect the antibody of endogenous factor, which can be divided into "blocking" antibody (type I) and "binding" antibody (type II). The former can block the formation of vitamin B12 and endogenous factor complex after binding with endogenous factor, so that vitamin B12 can not be absorbed, and the latter can block their absorption in the ileum by binding with endogenous factor vitamin B12 complex, eventually leading to pernicious anemia. In addition, AIG can be associated with a variety of other autoimmune diseases.

matters needing attention

In the above article, we emphasize the importance of the stomach for our human body. We suggest readers to protect their stomach in daily life. The above article introduces a kind of stomach disease, which is autoimmune gastritis. I believe we all know the pathological and clinical characteristics of autoimmune gastritis.