What is sickle cell nephropathy?

summary

The renal damage caused by sickle cell disease is called sickle cell nephropathy. Sickle cell disease is a kind of hemoglobin disease caused by abnormal hemoglobin. Hemolytic anemia is the most common, accompanied by low specific gravity polyuria. What is sickle cell nephropathy? Next, I'd like to share my views with you.

What is sickle cell nephropathy?

There are different degrees of hemolytic anemia, mild jaundice. Vascular occlusive crisis is a prominent manifestation, often in the trunk and limbs of severe pain, including visceral, bone, joint and muscle pain, especially metacarpal bone, accessory bone and finger (toe) bone infarction, infection, dehydration, hypoxia and acidosis as the inducement.

The corresponding symptoms and signs appeared in visceral and cerebrovascular infarction（ 2) Heterozygous sickle cell disease: usually asymptomatic, does not occur hemolytic anemia, it is also known as sickle cell tendency. Microcirculation disturbance occurs only under severe hypoxia, mainly in the straight blood vessels of renal medulla, because there is significant hypertonic, which makes red blood cells easy to dehydrate. Combined with the physiological characteristics of hypoxic tension and low pH value, red blood cells sickle, renal medulla blood flow stasis, and even blood vessel occlusion are caused. In severe cases, renal papillary necrosis may occur.

Hematuria may occur in homozygous or heterozygous patients. Hematuria is the most common manifestation of renal damage, which may be gross hematuria, but mainly microscopic hematuria. It may be caused by tiny necrosis of renal medulla and renal papilla, or glomerular hematuria.

matters needing attention

Strengthening self-care, keeping warm and avoiding fatigue are beneficial to prevent the occurrence of acute crisis and improve the prognosis. The combination therapy of traditional Chinese and Western medicine, western medicine application of vasodilators, analgesics, blood transfusion, antibiotics and oxygen, and traditional Chinese medicine can choose Astragalus, Salvia miltiorrhiza, Chuanxiong long-term use or according to the above dialectical medicine, the curative effect will be better.