What are the side effects of cyclophosphamide in the treatment of nephrotic syndrome

summary

Uncle Liu next door is over 60 years old. He used to be in good health. Recently, he often feels weak for no reason. He gets up at night and urinates more frequently. His blood pressure also rises. Some parts of his body even show edema. The doctor says it's kidney disease. Now I'll tell you about the side effects of cyclophosphamide in treating nephrotic syndrome.

What are the side effects of cyclophosphamide in the treatment of nephrotic syndrome

First, when using cyclophosphamide, we should pay attention to the side effects such as myelosuppression, toxic liver damage, alopecia, gonadal suppression, gastrointestinal reactions and hemorrhagic cystitis. In the treatment of refractory nephropathy, mycophenolate mofetil, ANOVA, etc.

Second: complicated or aggravated infection, causing water electrolyte imbalance, digestive system complications, neuropsychiatric symptoms, inhibition of growth and development, similar to adrenocortical hyperfunction, such as Cardiotropic obesity, full moon face, acne, hirsutism, weakness, hypokalemia, hypertension, diabetes, etc.

Third: malignant tumor, the more common is bladder cancer, reproductive system cancer, acute leukemia. The incidence was positively correlated with the cumulative total dose of the drug. Feehally reported that the drug can reduce circulating helper T cells, which can last for up to 6 months after drug withdrawal, which may be the reason why cancer is more likely to occur after using the drug.

matters needing attention

There are many treatment methods for nephrotic syndrome. Cyclophosphamide does have side effects in the treatment of nephrotic syndrome, which is easy to cause various complications, but it is not absolute. If we can follow the use method, generally it will not produce serious adverse consequences.