What are the symptoms of zhuoai syndrome?

summary

Zhuoei syndrome; Gastrinoma (gastrinoma) is a syndrome caused by gastrin producing tumor of pancreas or duodenum, which is characterized by obvious hypergastrinemia, high acid secretion and peptic ulcer. What are the symptoms of zhuoai syndrome? I'd like to share my views with you.

What are the symptoms of zhuoai syndrome?

The typical clinical manifestation is aggressive peptic ulcer, accompanied by ulcers occurring in atypical sites (up to 25% below the duodenal bulb) or after surgery, which is considered to be benign peptic ulcer.

In 25% - 40% of cases, the symptoms may be diarrhea, perforation, bleeding and obstruction. These complications may occur frequently and are life-threatening. However, the clinical manifestations of more than 50% of patients are difficult to differentiate from common peptic ulcer by X-ray and endoscopic findings. Moreover, Zollinger Ellison ulcer may expand and shrink as common peptic ulcer disease, Up to 25% of patients with Zollinger Ellison syndrome may not have ulcer at the time of diagnosis. Therefore, serum gastrin should be measured before any peptic ulcer operation.

For patients with corresponding clinical symptoms, X-ray shows duodenal or retrobulbar ulcers, large areas of edema, gastric and duodenal plica, and large amount of retention fluid in the stomach. The patients with high gastric acid secretion rate (>10mmol/h * or non operation patients) or patients who had undergone previous operations reached 5mmol/h using the most stimulant dose of histamine, >60% or >60% after gastric secretion. Zollinger Ellison syndrome should be suspected

matters needing attention

If the above treatment fails, total gastrectomy may be required. Although there are few nutritional complications, patients need to use vitamin B12 100 per month μ In patients with metastasis, chemotherapy with streptozocin and adriamycin can reduce tumor volume (in 50% - 60% of patients) and serum gastrin concentration. It is an effective adjuvant therapy for omeprazole or total gastrectomy. Chemotherapy is ineffective for patients with metastasis.