Propofol allergy: symptoms?

summary

Propofol is a new type of intravenous anesthetics with rapid onset, short action time and rapid recovery. At present, it has been widely used at home and abroad. In many countries, propofol has become the first choice for induction, maintenance and sedation of intravenous anesthesia. In addition, propofol has also been effectively used in painless surgery and examination, electroconvulsive therapy, electroconvulsive therapy and other fields. However, propofol plays an effective role in clinical practice, but also presents some adverse reactions that can not be ignored.

Propofol allergy: symptoms?

Propofol, as an anesthetic induction drug, has been reported to cause allergic reactions [4]. The allergic reaction induced by propofol may be related to the patient's history of hereditary allergy, the history of allergy to drugs and other substances, and the release of histamine caused by propofol. The clinical manifestations of propofol induced allergic reactions can be large red plaques or papules in the precordial area, which often occur several minutes after intravenous induction of propofol.

Very few patients may have anaphylactic shock, manifested as chest tightness, dyspnea, urticaria, decreased blood pressure, more serious cases may have laryngeal edema, bronchospasm, seriously endangering the life of patients.

If the patient has anaphylactic shock symptoms, propofol should be stopped immediately to keep the respiratory tract unobstructed and inhale pure oxygen; Dexamethasone, epinephrine and other antiallergic and antishock drugs were immediately injected intravenously, and crystal or colloid solution was rapidly infused; In case of laryngeal edema, airway spasm and severe insufficient ventilation, endotracheal intubation should be taken immediately. After the failure of endotracheal intubation under light vision, tracheotomy should be performed immediately to keep the airway unobstructed.

matters needing attention

Propofol is mainly based on emulsion as the carrier, long-term infusion will be accompanied by increased blood lipid levels. The long-chain triglyceride in emulsion is the main factor causing the increase of blood lipid level. In addition, the body in the stress state may lead to changes in the enzyme system related to lipid clearance and metabolism, so that the body's ability to metabolize and remove fat is reduced. At this time, the input of propofol aggravates the body's fat load and metabolic disorder, which may lead to hyperlipidemia. For patients with propofol, whether medical staff need to detect the changes of blood lipid is still a problem worthy of consideration.