Jaundice causes and symptoms?

summary

Jaundice is a common symptom and sign, which is caused by the increase of serum bilirubin concentration due to bilirubin metabolism disorder. Clinically, sclera, mucous membrane, skin and other tissues were dyed yellow. Because sclera contains more elastin and has strong affinity with bilirubin, scleral yellow staining is often detected first in jaundice patients than in mucosa and skin. When the serum total bilirubin was between 17.1 and 34.2 μ When jaundice can not be seen with naked eyes, it is called subclinical jaundice or recessive jaundice; When the serum total bilirubin concentration exceeds 34.2% μ The jaundice can be found in clinic, also known as dominant jaundice. Jaundice causes and symptoms? Let's talk about it

Jaundice causes and symptoms?

This is because the formation of unconjugated bilirubin increases after a large number of red blood cells are destroyed (hemolysis), and a large amount of unconjugated bilirubin is transported to the liver, which will inevitably increase the burden on the liver (hepatocytes). When the absorption and binding capacity of unconjugated bilirubin exceed the liver, the concentration of unconjugated bilirubin in the blood will increase. In addition, anemia caused by massive hemolysis makes hepatocytes in the state of hypoxia and ischemia, and their ability to absorb and combine unconjugated bilirubin will be further reduced, resulting in higher concentration of unconjugated bilirubin in the blood and jaundice.

This is due to the liver enzyme function is low, or due to late cirrhosis, or fulminant hepatitis, liver failure, the amount of residual functional hepatocytes in the liver is very small, can not absorb the blood unconjugated bilirubin, resulting in the concentration of unconjugated bilirubin in the blood is higher and jaundice. Neonatal physiological jaundice is also due to this reason.

In patients with hepatitis, because of extensive damage (degeneration and necrosis) of hepatocytes, the uptake and binding of unconjugated bilirubin by hepatocytes are obstructed, so the concentration of unconjugated bilirubin in serum is increased, while some undamaged hepatocytes can continue to absorb and bind unconjugated bilirubin, making it change into conjugated bilirubin, However, some of the conjugated bilirubin could not be excreted in the bile capillaries, but flowed back into the liver lymph and blood through the necrotic hepatocyte space, resulting in the increase of serum conjugated bilirubin concentration and jaundice. At this time, the patient's transaminase will increase.

matters needing attention

Diet Festival, do not drink, do not eat dirty products and wanton food spicy hot fat sweet things. Jaundice patients should pay attention to rest, keep a good mood, diet should be light. Once the disease is found, it should be isolated and treated immediately, and its tableware and utensils should be detoxified, and its excreta should be deeply buried or disinfected with bleaching powder. After the treatment of jaundice subsided, it is not appropriate to stop the drug immediately, should continue to treat according to the condition, in order to avoid recurrence.