What symptom does chronic gout have?

summary

Gout is a crystal related arthritis caused by monosodium urate (MSU) deposition, which is directly related to hyperuricemia caused by purine metabolism disorder and (or) reduced uric acid excretion. It belongs to the category of metabolic rheumatism. Gout can be complicated with renal disease, severe joint damage, renal function damage, often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and coronary heart disease. What symptom does chronic gout have? Let's talk about it

What symptom does chronic gout have?

The first few attacks usually involve only one joint, usually lasting only a few days, but later they can invade multiple joints simultaneously or successively. If untreated, it can last for several weeks. Finally, local symptoms and signs subsided and joint function recovered. After the onset of acute arthritis is relieved, there are generally no obvious sequelae symptoms, sometimes only the skin color of the attack site is deepened, showing dark red or purplish red, desquamation, itching, which is called asymptomatic intermission.

The length of asymptomatic intermission varies greatly, and becomes shorter and shorter with the progress of the disease. If not prevented, it will attack several times a year, with chronic joint symptoms, permanent destructive joint deformity and limited hand foot joint movement. In a few cases, sacroiliac, sternoclavicular or cervical joints may also be involved.

Urate deposition is common in the wall of mucous sac and tendon sheath. In the hands and feet, enlarged gout stones and chalky urate crystal fragments can be seen. Cyclosporine induced gout usually occurs in the central joints, such as the hip, sacroiliac joints, and also in the hands, even damaging the renal tubules.

matters needing attention

Soybean food is rich in protein, isoflavones and polyunsaturated fatty acids. Six epidemiological surveys showed that soy food intake had nothing to do with serum uric acid level, hyperuricemia and gout. Five intervention trials found that although soy protein increased serum uric acid level, compared with the intake of Asians, the impact of elevated serum uric acid level on clinical practice could be ignored. A recent domestic study found that the level of serum uric acid in patients with hyperuricemia was significantly lower when they were given beans high protein diet for 3 months.