What is common variant immunodeficiency in children?

summary

Common variable immunodeficiency (CVID) is a kind of common hypogammaglobulinemia, which was once known as acquired (or adult, delayed) hypogammaglobulinemia. Let's share my experience with you.

What is common variant immunodeficiency in children?

Repeated bacterial infections, such as acute and chronic sinusitis, otitis media, pharyngitis, tracheitis and pneumonia, can lead to bronchiectasis. The pathogenic bacteria were Haemophilus influenzae, Streptococcus, Staphylococcus, pneumococcus, etc. Other pathogens such as Mycoplasma, Candida, Pneumocystis carinii, herpes simplex and herpes zoster virus can also infect CVID patients. About 10% of the patients had central nervous system infection, such as chronic purulent meningitis and viral encephalitis. The severity of infection is not as serious as XLA, and it is often chronic. illness

Gastrointestinal symptoms include chronic malabsorption syndrome, steatosis, folic acid and vitamin B12 deficiency, lactose intolerance, disaccharidase deficiency, protein loss enteropathy, etc. Flagellate infection is an important cause of intestinal symptoms. Nodular lymphohistiocytosis was found in some cases. Endoscopy revealed multiple lymphoid follicles and germinal centers in the lamina propria of the small intestine. Gastroenterography showed rough, uneven or polypoid intestinal mucosa. Intestinal mucosa biopsy showed that plasma cells in lamina propria were significantly reduced or even absent.

Autoimmune diseases and tumor CVID are easy to be complicated with a variety of autoimmune diseases, and the incidence of malignant tumor is also high, with an incidence of 8.5% - 10%. Including leukemia, lymphoreticular tissue tumor, gastric cancer and colon cancer.

matters needing attention

Maternal health care has known that the occurrence of some immunodeficiency diseases is closely related to embryonic dysplasia. If a pregnant woman is exposed to radiation, chemical treatment or virus infection (especially rubella virus infection), the immune system of the fetus may be damaged, especially in the early pregnancy, which may involve multiple systems including the immune system.