What is hypergastrinemia?

summary

Gastrin is an important gastrointestinal hormone, which is mainly secreted by G cells. G cells are typical open cells, most of which are located in antrum, followed by fundus, duodenum and jejunum. D cells of human islets can also secrete gastrin. Hypergastrinemia can be divided into two types: hypergastrinemia with high gastric acid and hypergastrinemia with or without low gastric acid. In patients with gastrinoma, the serum gastrin level is very high, and most of them are accompanied by hyperplasia and hypertrophy of gastric mucosa.

What is hypergastrinemia?

Primary hypergastrinemia: CT cells proliferate due to genetic or chronic inflammation and Helicobacter pylori infection, resulting in increased gastrin secretion and absorption into the blood, resulting in hypergastrinemia.

Secondary hypergastrinemia: due to chronic atrophic gastritis, the number of parietal cells is reduced, the ability of acid secretion is weakened, and the content of gastric acid in gastric juice is reduced (pH > 4). Through the feedback mechanism, gastric G cells secrete a large amount of gastrin, resulting in hypergastrinemia.

Hypogastric acid or no acid hypergastrinemia: seen in gastric ulcer, type a atrophic gastritis, after vagotomy, hyperthyroidism. Hypogastrinemia: seen in type B atrophic gastritis, gastroesophageal reflux.

matters needing attention

Diet: eat less and eat more. Less food can shorten the time of stimulating gastric acid secretion, reduce the expansion of gastric antrum and the secretion of gastrin. More meals, 4-5 times during the day. Try to adapt the food to the habits of the sick children, low-fat, moderate amount of protein and carbohydrate. Fried, spicy food should be taboo.